Increased synaptosomal dopamine content and brain concentration of paraquat produced by selective dithiocarbamates
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چکیده
منابع مشابه
The kinetics of the inhibition of rat brain synaptosomal dopamine uptake by manganous ions [proceedings].
~ [ ~ H l F u c o s e (1.4pCi/mg of synaptosomal protein: sp. radioactivity 6.7Ci/mmol) and various concentrations of L-fucose were incubated with Ficoll-prepared synaptosomes. After lysis, fraction S was assayed for protein content and radioactivity. 33 nmol/mg of protein. Therefore under the conditions adopted in the present study the fucose turnover in synaptosomal fucosylglycoprotein appear...
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Tubulin purified by the method of Shelanski, M. L., Gaskin, F., and Cantor, R. C. ((1973) Proc. N&Z. Acud. Sci. U. S. A. 70, 765-768) contains significant levels of glutamate dehydrogenase resulting from hypotonic shock of mitochondria. Presumably, the anionic character of tubulin leads to ionic associations with compartmentalized proteins not normally associated with tubulin in Go. A new sucro...
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The regulation of dopamine and serotonin synthesis in rat brain striatal synaptosomes has been studied using HPLC methods. Noradrenaline was shown to markedly inhibit both the synthesis of dopamine and serotonin. The response of the synaptosomes to the concentrations of noradrenaline appeared to be biphasic, a very effective inhibition occurring at low concentrations (1-5 µm) and a relativ...
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متن کاملPCB-induced inhibition of the vesicular monoamine transporter predicts reductions in synaptosomal dopamine content.
Both Aroclor mixtures and individual non-coplanar polychlorinated biphenyl (PCB) congeners reduce dopamine (DA) concentrations in cells in culture and in the brains of developing and adult laboratory animals. These reductions may involve inhibition of the dopamine transporter (DAT) and the vesicular monoamine transporter (VMAT) responsible, respectively, for the uptake of extracellular DA and t...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2003
ISSN: 0022-3042,1471-4159
DOI: 10.1046/j.1471-4159.2003.01773.x